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#研究#困成狗？谈谈睡眠研究的遗传发现之旅( 三 )


随着基因组学检测技术成本降低以及各类群体遗传学项目所带来的丰富样本资源，诸如表观基因组关联分析以及空间转录组等新兴技术将会进一步帮助人类来解锁睡眠健康的奥秘。
参考资料：
1. Lin, L., 1999. The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the HypocretinReceptor 2 Gene.Cell, 98, pp.365-376.
2. Desautels, A., 2001. Identification of a Major Susceptibility Locus for Restless Legs Syndrome on Chromosome 12q.The American Journal of Human Genetics, 69, pp.1266-1270.
3. Stefansson, H., 2007. A Genetic Risk Factor for Periodic Limb Movements in Sleep.New England Journal of Medicine, 357, pp.639-647.
4. Winkelmann, J., 2007. Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.Nature Genetics, 39, pp.1000-1006.
5. Mignot, E., 2007. A step forward for restless legs syndrome.Nature Genetics, 39, pp.938-939.
6. Hu, Y., 2016. GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person.Nature Communications, 7.
7. Liang, J., 2019. Sequencing Analysis at 8p23 Identifies Multiple Rare Variants in DLC1 Associated with Sleep-Related Oxyhemoglobin Saturation Level.The American Journal of Human Genetics, 105, pp.1057-1068.
8. Liu, Z., 2020. Acute Sleep-Wake Cycle Shift Results in Community Alteration of Human Gut Microbiome.mSphere, 5.
9. Wittenbrink, N., 2018. High-accuracy determination of internal circadian time from a single blood sample.Journal of Clinical Investigation, 128, pp.3826-3839.
10. Carroll, J., Irwin, M., Levine, M., Seeman, T., Absher, D., Assimes, T. and Horvath, S., 2017. Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women’s Health Initiative Study.Biological Psychiatry, 81, pp.136-144.
【 #研究#困成狗？谈谈睡眠研究的遗传发现之旅】11. Li, X., 2019. Association between sleep disordered breathing and epigenetic age acceleration: Evidence from the Multi-Ethnic Study of Atherosclerosis.EBioMedicine, 50, pp.387-394.


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